タイトル | The conformational landscape of human transthyretin revealed by cryo-EM |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2023年12月18日 (構造データの登録日) |
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著者 | Basanta B / Nugroho K / Yan N / Kline GM / Powers ET / Tsai FJ / Wu M / Hansel-Harris A / Chen J / Forli S ...Basanta B / Nugroho K / Yan N / Kline GM / Powers ET / Tsai FJ / Wu M / Hansel-Harris A / Chen J / Forli S / Kelly JW / Lander GC |
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リンク | PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.7 - 4.1 Å |
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構造データ | EMDB-43160, PDB-8ve0: Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation 手法: EM (単粒子) / 解像度: 3.1 Å EMDB-43161, PDB-8ve1: Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation 手法: EM (単粒子) / 解像度: 2.7 Å EMDB-43162, PDB-8ve2: Unliganded human transthyretin in the canonical conformation 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-43163, PDB-8ve3: Unliganded human transthyretin in the compressed conformation 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-43164, PDB-8ve4: Unliganded human transthyretin in the frayed conformation 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-43165, PDB-8ve5: (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation 手法: EM (単粒子) / 解像度: 3.4 Å EMDB-43166, PDB-8ve6: (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation 手法: EM (単粒子) / 解像度: 4.1 Å |
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化合物 | ChemComp-1WZ: 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid
ChemComp-P2C: 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSPORT PROTEIN / Amyloidosis |
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