EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
ジャーナル・号・ページ	Cell Rep, Vol. 43, Issue 5, Page 114171, Year 2024
掲載日	2024年5月28日
著者	Yuhe R Yang / Julianna Han / Hailee R Perrett / Sara T Richey / Alesandra J Rodriguez / Abigail M Jackson / Rebecca A Gillespie / Sarah O'Connell / Julie E Raab / Lauren Y Cominsky / Ankita Chopde / Masaru Kanekiyo / Katherine V Houser / Grace L Chen / Adrian B McDermott / Sarah F Andrews / Andrew B Ward /
PubMed 要旨	Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin nanoparticle vaccine displaying H2 ...Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin nanoparticle vaccine displaying H2 hemagglutinin (HA) in H2-naive and H2-exposed adults enabled us to perform comprehensive structural and biochemical characterization of immune memory on the breadth and diversity of the polyclonal serum antibody response elicited. We temporally map the epitopes targeted by serum antibodies after vaccine prime and boost, revealing that previous H2 exposure results in higher responses to the variable HA head domain. In contrast, initial responses in H2-naive participants are dominated by antibodies targeting conserved epitopes. We use cryoelectron microscopy and monoclonal B cell isolation to describe the molecular details of cross-reactive antibodies targeting conserved epitopes on the HA head, including the receptor-binding site and a new site of vulnerability deemed the medial junction. Our findings accentuate the impact of pre-existing influenza exposure on serum antibody responses post-vaccination.
リンク	Cell Rep / PubMed:38717904 / PubMed Central
手法	EM (単粒子)
解像度	20.0 Å
構造データ	EMDB-41514: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-1 week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41515: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-1 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41516: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-1 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41517: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-1 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41518: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-2 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41519: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 2-1 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41520: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-2 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41521: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 1-2 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41522: Polyclonal immune complex of fab binding the H2 HA from serum of subject 1-3 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41541: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 3-3 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41543: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 3-3 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41544: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 3-3 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41545: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-1 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41546: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-1 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41547: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-1 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41548: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-1 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41549: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-2 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41550: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-2 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41551: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-2 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41552: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-2 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41553: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-3 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41554: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-3 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41555: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-3 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41556: Polyclonal immune complex of Fab binding the H2 HA from serum of subject 4-3 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41557: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 1-1 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41558: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 1-1 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41559: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 1-1 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41560: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 1-1 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41561: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 2-2 at week 0 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41562: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 2-2 at week 4 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41563: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 2-2 at week 16 手法: EM (単粒子) / 解像度: 20.0 Å EMDB-41564: Polyclonal immune complex of Fab binding the H1 HA from serum of subject 2-2 at week 20 手法: EM (単粒子) / 解像度: 20.0 Å
由来	Homo sapiens (ヒト)