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-Structure paper
タイトル | Structure of the 70S ribosome from human pathogen Staphylococcus aureus. |
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ジャーナル・号・ページ | Nucleic Acids Res, Vol. 44, Issue 21, Page 10491-10504, Year 2016 |
掲載日 | 2016年12月1日 |
著者 | Iskander Khusainov / Quentin Vicens / Anthony Bochler / François Grosse / Alexander Myasnikov / Jean-François Ménétret / Johana Chicher / Stefano Marzi / Pascale Romby / Gulnara Yusupova / Marat Yusupov / Yaser Hashem / |
PubMed 要旨 | Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact ...Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen. |
リンク | Nucleic Acids Res / PubMed:27906650 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.8 Å |
構造データ | |
化合物 | ChemComp-MG: ChemComp-O: ChemComp-ZN: ChemComp-HOH: |
由来 |
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キーワード | RIBOSOME / pathogenic ribosome / bL31 B-type |