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-Structure paper
タイトル | The infectious particle of insect-borne totivirus-like Omono River virus has raised ridges and lacks fibre complexes. |
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ジャーナル・号・ページ | Sci Rep, Vol. 6, Page 33170, Year 2016 |
掲載日 | 2016年9月12日 |
著者 | Kenta Okamoto / Naoyuki Miyazaki / Daniel S D Larsson / Daisuke Kobayashi / Martin Svenda / Kerstin Mühlig / Filipe R N C Maia / Laura H Gunn / Haruhiko Isawa / Mutsuo Kobayashi / Kyoko Sawabe / Kazuyoshi Murata / Janos Hajdu / |
PubMed 要旨 | Omono River virus (OmRV) is a double-stranded RNA virus isolated from Culex mosquitos, and it belongs to a group of unassigned insect viruses that appear to be related to Totiviridae. This paper ...Omono River virus (OmRV) is a double-stranded RNA virus isolated from Culex mosquitos, and it belongs to a group of unassigned insect viruses that appear to be related to Totiviridae. This paper describes electron cryo-microscopy (cryoEM) structures for the intact OmRV virion to 8.9 Å resolution and the structure of the empty virus-like-particle, that lacks RNA, to 8.3 Å resolution. The icosahedral capsid contains 120-subunits and resembles another closely related arthropod-borne totivirus-like virus, the infectious myonecrosis virus (IMNV) from shrimps. Both viruses have an elevated plateau around their icosahedral 5-fold axes, surrounded by a deep canyon. Sequence and structural analysis suggests that this plateau region is mainly composed of the extended C-terminal region of the capsid proteins. In contrast to IMNV, the infectious form of OmRV lacks extensive fibre complexes at its 5-fold axes as directly confirmed by a contrast-enhancement technique, using Zernike phase-contrast cryo-EM. Instead, these fibre complexes are replaced by a short "plug" structure at the five-fold axes of OmRV. OmRV and IMNV have acquired an extracellular phase, and the structures at the five-fold axes may be significant in adaptation to cell-to-cell transmission in metazoan hosts. |
リンク | Sci Rep / PubMed:27616740 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 8.3 - 8.9 Å |
構造データ | EMDB-3350: EMDB-3351: |