+検索条件
-Structure paper
タイトル | TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death. |
---|---|
ジャーナル・号・ページ | Cell, Vol. 185, Issue 13, Page 2370-2386.e18, Year 2022 |
掲載日 | 2022年6月23日 |
著者 | Dongli Yu / Wen Song / Eddie Yong Jun Tan / Li Liu / Yu Cao / Jan Jirschitzka / Ertong Li / Elke Logemann / Chenrui Xu / Shijia Huang / Aolin Jia / Xiaoyu Chang / Zhifu Han / Bin Wu / Paul Schulze-Lefert / Jijie Chai / |
PubMed 要旨 | 2',3'-cAMP is a positional isomer of the well-established second messenger 3',5'-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide monophosphate (cNMP). ...2',3'-cAMP is a positional isomer of the well-established second messenger 3',5'-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide monophosphate (cNMP). Toll/interleukin-1 receptor (TIR) domains of nucleotide-binding leucine-rich repeat (NLR) immune receptors have the NADase function necessary but insufficient to activate plant immune responses. Here, we show that plant TIR proteins, besides being NADases, act as 2',3'-cAMP/cGMP synthetases by hydrolyzing RNA/DNA. Structural data show that a TIR domain adopts distinct oligomers with mutually exclusive NADase and synthetase activity. Mutations specifically disrupting the synthetase activity abrogate TIR-mediated cell death in Nicotiana benthamiana (Nb), supporting an important role for these cNMPs in TIR signaling. Furthermore, the Arabidopsis negative regulator of TIR-NLR signaling, NUDT7, displays 2',3'-cAMP/cGMP but not 3',5'-cAMP/cGMP phosphodiesterase activity and suppresses cell death activity of TIRs in Nb. Our study identifies a family of 2',3'-cAMP/cGMP synthetases and establishes a critical role for them in plant immune responses. |
リンク | Cell / PubMed:35597242 |
手法 | EM (らせん対称) / EM (単粒子) |
解像度 | 3.0 - 3.8 Å |
構造データ | EMDB-32121: TIR-dsDNA initial state complex EMDB-32125: L7-TIR nucleic acids complex intermediate complex |
化合物 | ChemComp-ACK: |
由来 |
|
キーワード | HYDROLASE / Nucleic acid hydrolysis complex / HYDROLASE/DNA / plant innate immune receptor / nucleic acids / 2' / 3'cNMP / HYDROLASE-DNA COMPLEX |