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-Structure paper
タイトル | The structure of the dynactin complex and its interaction with dynein. |
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ジャーナル・号・ページ | Science, Vol. 347, Issue 6229, Page 1441-1446, Year 2015 |
掲載日 | 2015年3月27日 |
著者 | Linas Urnavicius / Kai Zhang / Aristides G Diamant / Carina Motz / Max A Schlager / Minmin Yu / Nisha A Patel / Carol V Robinson / Andrew P Carter / |
PubMed 要旨 | Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 angstroms. Our ...Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 angstroms. Our reconstruction reveals how dynactin is built around a filament containing eight copies of the actin-related protein Arp1 and one of β-actin. The filament is capped at each end by distinct protein complexes, and its length is defined by elongated peptides that emerge from the α-helical shoulder domain. A further 8.2 angstrom structure of the complex between dynein, dynactin, and the motility-inducing cargo adaptor Bicaudal-D2 shows how the translational symmetry of the dynein tail matches that of the dynactin filament. The Bicaudal-D2 coiled coil runs between dynein and dynactin to stabilize the mutually dependent interactions between all three components. |
リンク | Science / PubMed:25814576 / PubMed Central |
手法 | EM (単粒子) / X線回折 |
解像度 | 3.5 - 12.5 Å |
構造データ | EMDB-2854: EMDB-2855: EMDB-2856: CryoEM structure of dynactin complex at 4.1 angstrom resolution EMDB-2857: CryoEM reconstruction of dynactin complex from pig brain at 4.0 Angstrom resolution overall EMDB-2860: Electron cryo-microscopy of dynein/dynactin/GFP-BICD2N complex EMDB-2861: EMDB-2862: PDB-5afr: |
化合物 | ChemComp-ADP: ChemComp-ATP: |
由来 |
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キーワード | STRUCTURAL PROTEIN / DYNEIN CO-FACTOR / ACTIN-LIKE FILAMENT / CELLULAR CARGO TRANSPORT / MOTOR PROTEIN / DYNEIN / TAIL / HEAVY CHAIN / DYNACTIN / BICD2 / MOTOR / TRANSPORT |