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-Structure paper
タイトル | Cryo-EM Structure of a Possum Enterovirus. |
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ジャーナル・号・ページ | Viruses, Vol. 14, Issue 2, Year 2022 |
掲載日 | 2022年2月3日 |
著者 | Ivy Wang / Sandeep K Gupta / Guillaume Ems / Nadishka Jayawardena / Mike Strauss / Mihnea Bostina / |
PubMed 要旨 | Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess ...Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess the structural diversity of these picornaviruses. The capsid structure, determined to ~3 Å resolution by single particle analysis, exhibits a largely smooth surface, similar to EV-F3 (formerly BEV-2). Although the cellular receptor is not known, the absence of charged residues on the outer surface of the canyon suggest a different receptor type than for EV-F3. Density for the pocket factor is clear, with the entrance to the pocket being smaller than for other enteroviruses. |
リンク | Viruses / PubMed:35215909 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.96 Å |
構造データ | EMDB-25905, PDB-7thx: |
化合物 | ChemComp-SPH: ChemComp-K: ChemComp-HOH: |
由来 |
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キーワード | VIRUS / enterovirus / icosahedral |