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-Structure paper
タイトル | Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis. |
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ジャーナル・号・ページ | Commun Biol, Vol. 5, Issue 1, Page 72, Year 2022 |
掲載日 | 2022年1月20日 |
著者 | Yuewei Wang / Tong Huo / Yu-Jung Tseng / Lan Dang / Zhili Yu / Wenjuan Yu / Zachary Foulks / Rebecca L Murdaugh / Steven J Ludtke / Daisuke Nakada / Zhao Wang / |
PubMed 要旨 | Early diagnosis of acute myeloid leukemia (AML) in the pre-leukemic stage remains a clinical challenge, as pre-leukemic patients show no symptoms, lacking any known morphological or numerical ...Early diagnosis of acute myeloid leukemia (AML) in the pre-leukemic stage remains a clinical challenge, as pre-leukemic patients show no symptoms, lacking any known morphological or numerical abnormalities in blood cells. Here, we demonstrate that platelets with structurally abnormal mitochondria emerge at the pre-leukemic phase of AML, preceding detectable changes in blood cell counts or detection of leukemic blasts in blood. We visualized frozen-hydrated platelets from mice at different time points during AML development in situ using electron cryo-tomography (cryo-ET) and identified intracellular organelles through an unbiased semi-automatic process followed by quantitative measurement. A large proportion of platelets exhibited changes in the overall shape and depletion of organelles in AML. Notably, 23% of platelets in pre-leukemic cells exhibit abnormal, round mitochondria with unfolded cristae, accompanied by a significant drop in ATP levels and altered expression of metabolism-related gene signatures. Our study demonstrates that detectable structural changes in pre-leukemic platelets may serve as a biomarker for the early diagnosis of AML. |
リンク | Commun Biol / PubMed:35058565 / PubMed Central |
手法 | EM (トモグラフィー) |
構造データ | EMDB-24287: EMDB-24288: EMDB-24289: EMDB-24291: EMDB-24298: |
由来 |
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