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-Structure paper
タイトル | Highly conserved protective epitopes on influenza B viruses. |
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ジャーナル・号・ページ | Science, Vol. 337, Issue 6100, Page 1343-1348, Year 2012 |
掲載日 | 2012年9月14日 |
著者 | Cyrille Dreyfus / Nick S Laursen / Ted Kwaks / David Zuijdgeest / Reza Khayat / Damian C Ekiert / Jeong Hyun Lee / Zoltan Metlagel / Miriam V Bujny / Mandy Jongeneelen / Remko van der Vlugt / Mohammed Lamrani / Hans J W M Korse / Eric Geelen / Özcan Sahin / Martijn Sieuwerts / Just P J Brakenhoff / Ronald Vogels / Olive T W Li / Leo L M Poon / Malik Peiris / Wouter Koudstaal / Andrew B Ward / Ian A Wilson / Jaap Goudsmit / Robert H E Friesen / |
PubMed 要旨 | Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. ...Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses. |
リンク | Science / PubMed:22878502 / PubMed Central |
手法 | EM (単粒子) / X線回折 |
解像度 | 1.71 - 19.0 Å |
構造データ | EMDB-2143: EMDB-2144: EMDB-2145: EMDB-2146: EMDB-2147: EMDB-2148: EMDB-2149: EMDB-2150: PDB-4fqh: PDB-4fqi: PDB-4fqj: PDB-4fqk: PDB-4fql: PDB-4fqm: PDB-4fqv: PDB-4fqy: |
化合物 | ChemComp-EDO: ChemComp-NO3: ChemComp-HOH: ChemComp-NAG: ChemComp-GOL: |
由来 |
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キーワード | IMMUNE SYSTEM / neutralizing antibodies / antibody affinity / antigens / epitope / glycosylation / hemagglutinin glycoproteins / immunoglobulin Fab fragment / influenza virus / influenza vaccines / membrane fusion / VIRAL PROTEIN/IMMUNE SYSTEM / epitopes / immunoglobulin Fab fragments / H5N1 subtype / avian flu / envelope protein / VIRAL PROTEIN-IMMUNE SYSTEM complex / monoclonal / immunoglobulin / antibody / Fab fragment / viral / Influenza B virus / VIRAL PROTEIN / Hemagglutinin / viral fusion protein / virus attachment and entry / immune recognition |