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-Structure paper
タイトル | Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices. |
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ジャーナル・号・ページ | Cell, Vol. 186, Issue 24, Page 5308-5327.e25, Year 2023 |
掲載日 | 2023年11月22日 |
著者 | Ida M A Jentoft / Felix J B Bäuerlein / Luisa M Welp / Benjamin H Cooper / Arsen Petrovic / Chun So / Sarah Mae Penir / Antonio Z Politi / Yehor Horokhovskyi / Iina Takala / Heike Eckel / Rüdiger Moltrecht / Peter Lénárt / Tommaso Cavazza / Juliane Liepe / Nils Brose / Henning Urlaub / Rubén Fernández-Busnadiego / Melina Schuh / |
PubMed 要旨 | Mammalian oocytes are filled with poorly understood structures called cytoplasmic lattices. First discovered in the 1960s and speculated to correspond to mammalian yolk, ribosomal arrays, or ...Mammalian oocytes are filled with poorly understood structures called cytoplasmic lattices. First discovered in the 1960s and speculated to correspond to mammalian yolk, ribosomal arrays, or intermediate filaments, their function has remained enigmatic to date. Here, we show that cytoplasmic lattices are sites where oocytes store essential proteins for early embryonic development. Using super-resolution light microscopy and cryoelectron tomography, we show that cytoplasmic lattices are composed of filaments with a high surface area, which contain PADI6 and subcortical maternal complex proteins. The lattices associate with many proteins critical for embryonic development, including proteins that control epigenetic reprogramming of the preimplantation embryo. Loss of cytoplasmic lattices by knocking out PADI6 or the subcortical maternal complex prevents the accumulation of these proteins and results in early embryonic arrest. Our work suggests that cytoplasmic lattices enrich maternally provided proteins to prevent their premature degradation and cellular activity, thereby enabling early mammalian development. |
リンク | Cell / PubMed:37922900 |
手法 | EM (サブトモグラム平均) / EM (トモグラフィー) |
解像度 | 30.0 Å |
構造データ | EMDB-16458: Electron cryo-tomography and subtomogram averaging of cytoplasmic lattice filaments from mammalian oocytes EMDB-16472: In situ cryo-electron tomogram of cytoplasmic lattice filaments from a mouse oocyte |
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