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タイトル | Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly. |
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ジャーナル・号・ページ | Commun Biol, Vol. 5, Issue 1, Page 1210, Year 2022 |
掲載日 | 2022年11月10日 |
![]() | Lesley J Calder / Thomas Calcraft / Saira Hussain / Ruth Harvey / Peter B Rosenthal / ![]() |
PubMed 要旨 | SARS-CoV-2 is a lipid-enveloped Betacoronavirus and cause of the Covid-19 pandemic. To study the three-dimensional architecture of the virus, we perform electron cryotomography (cryo-ET) on SARS-Cov- ...SARS-CoV-2 is a lipid-enveloped Betacoronavirus and cause of the Covid-19 pandemic. To study the three-dimensional architecture of the virus, we perform electron cryotomography (cryo-ET) on SARS-Cov-2 virions and three variants revealing particles of regular cylindrical morphology. The ribonucleoprotein particles packaging the genome in the virion interior form a dense, double layer assembly with a cylindrical shape related to the overall particle morphology. This organisation suggests structural interactions important to virus assembly. |
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手法 | EM (サブトモグラム平均) / EM (トモグラフィー) |
解像度 | 27.75 - 44.4 Å |
構造データ | ![]() EMDB-15181: Prefusion spike of SARS-CoV-2 (Wuhan), closed conformation ![]() EMDB-15182: Electron cryotomography of SARS-CoV-2 virions ![]() EMDB-15183: Whole SARS-CoV-2 (Wuhan) virion ![]() EMDB-15185: Prefusion spike of SARS-CoV-2 (Wuhan), 1-RBD-up conformation |