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-Structure paper
タイトル | A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination. |
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ジャーナル・号・ページ | Cell Rep, Vol. 40, Issue 8, Page 111276, Year 2022 |
掲載日 | 2022年8月23日 |
著者 | Jeffrey Seow / Hataf Khan / Annachiara Rosa / Valeria Calvaresi / Carl Graham / Suzanne Pickering / Valerie E Pye / Nora B Cronin / Isabella Huettner / Michael H Malim / Argyris Politis / Peter Cherepanov / Katie J Doores / |
PubMed 要旨 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for neutralizing antibodies elicited following both infection and vaccination. While extensive research has shown that ...Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for neutralizing antibodies elicited following both infection and vaccination. While extensive research has shown that the receptor binding domain (RBD) and, to a lesser extent, the N-terminal domain (NTD) are the predominant targets for neutralizing antibodies, identification of neutralizing epitopes beyond these regions is important for informing vaccine development and understanding antibody-mediated immune escape. Here, we identify a class of broadly neutralizing antibodies that bind an epitope on the spike subdomain 1 (SD1) and that have arisen from infection or vaccination. Using cryo-electron microscopy (cryo-EM) and hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS), we show that SD1-specific antibody P008_60 binds an epitope that is not accessible within the canonical prefusion states of the SARS-CoV-2 spike, suggesting a transient conformation of the viral glycoprotein that is vulnerable to neutralization. |
リンク | Cell Rep / PubMed:35981534 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 4.31 Å |
構造データ | EMDB-14591, PDB-7zbu: |
化合物 | ChemComp-NAG: ChemComp-3Q9: |
由来 |
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キーワード | VIRAL PROTEIN / covid-19 / SARS-CoV-2 / spike / neutralizing antibody / immunity |