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-Structure paper
タイトル | Electron cryotomography reveals the portal in the herpesvirus capsid. |
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ジャーナル・号・ページ | J Virol, Vol. 81, Issue 4, Page 2065-2068, Year 2007 |
掲載日 | 2006年12月6日 |
著者 | Juan T Chang / Michael F Schmid / Frazer J Rixon / Wah Chiu / |
PubMed 要旨 | Herpes simplex virus type 1 is a human pathogen responsible for a range of illnesses from cold sores to encephalitis. The icosahedral capsid has a portal at one fivefold vertex which, by analogy to ...Herpes simplex virus type 1 is a human pathogen responsible for a range of illnesses from cold sores to encephalitis. The icosahedral capsid has a portal at one fivefold vertex which, by analogy to portal-containing phages, is believed to mediate genome entry and exit. We used electron cryotomography to determine the structure of capsids lacking pentons. The portal vertex appears different from pentons, being located partially inside the capsid shell, a position equivalent to that of bacteriophage portals. Such similarity in portal organization supports the idea of the evolutionary relatedness of these viruses. |
リンク | J Virol / PubMed:17151101 / PubMed Central |
手法 | EM (サブトモグラム平均) |
解像度 | 30.0 - 57.0 Å |
構造データ | EMDB-1305: EMDB-1306: EMDB-1307: EMDB-1308: |