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-Structure paper
タイトル | A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus. |
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ジャーナル・号・ページ | Sci Adv, Vol. 8, Issue 19, Page eabj6894, Year 2022 |
掲載日 | 2022年5月13日 |
著者 | Monique Merchant / Carlos P Mata / Yangci Liu / Haoming Zhai / Anna V Protasio / Yorgo Modis / |
PubMed 要旨 | Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus ...Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm , with an envelope protein genetically related to G-G glycoproteins from the family Phenuiviridae. A cryo-EM structure of Atlas G reveals a class II viral membrane fusion protein fold not previously seen in retroviruses. Atlas G has the structural hallmarks of an active fusogen. Atlas G trimers insert into membranes with endosomal lipid compositions and low pH. When expressed on the plasma membrane, Atlas G has cell-cell fusion activity. With its preserved biological activities, Atlas G has the potential to acquire a cellular function. Our work reveals structural plasticity in reverse-transcribing RNA viruses. |
リンク | Sci Adv / PubMed:35544562 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.76 Å |
構造データ | EMDB-11630, PDB-7a4a: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | VIRAL PROTEIN / class II membrane fusion protein; retroviral envelope protein (Env); lipid binding protein; disulfide bonding |