タイトル Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. ジャーナル・号・ページ J. Am. Chem. Soc. , Vol. 143, Page 8193-8207, Year 2021掲載日 2021年2月7日 (構造データの登録日) 著者Zhu, W. / Doubleday, P.F. / Butrin, A. / Weerawarna, P.M. / Melani, R.D. / Catlin, D.S. / Dwight, T.A. / Liu, D. / Kelleher, N.L. / Silverman, R.B. リンク J. Am. Chem. Soc. / PubMed:34014654手法 X線回折 解像度 1.95 - 2.1 Å 構造データ PDB-7lnm : 構造ビューア Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid手法 : X-RAY DIFFRACTION / 解像度 : 2.0 Å
PDB-7lom : 構造ビューア Ornithine Aminotransferase (OAT) soaked with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid手法 : X-RAY DIFFRACTION / 解像度 : 2.1 Å
PDB-7lon : 構造ビューア Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid手法 : X-RAY DIFFRACTION / 解像度 : 1.95 Å
化合物 ChemComp-Y7S : 構造ビューア (1~{R},3~{S},4~{R})-3-methyl-4-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclopentane-1-carboxylic acid
ChemComp-Y8P : 構造ビューア (3~{S},4~{S})-4-methyl-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid
ChemComp-YCD : 構造ビューア (4~{R})-4-(fluoranylmethyl)-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid
ChemComp-7QP : 構造ビューア (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid
由来 homo sapiens (ヒト) キーワード TRANSFERASE/Inactivator / Ornithine Aminotransferase / OAT (エンバク) / aminotransferase (アミノ基転移酵素) / inactivator / inhibitor (酵素阻害剤) / TRANSFERASE (転移酵素) / TRANSFERASE-Inactivator complex