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-Structure paper
Title | Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase. |
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Journal, issue, pages | Nat Commun, Vol. 15, Page 5167-5167, Year 2024 |
Publish date | Nov 12, 2023 (structure data deposition date) |
Authors | Yamada, K. / Mendoza, J. / Koutmos, M. |
External links | Nat Commun / PubMed:38886362 |
Methods | X-ray diffraction |
Resolution | 2.83 - 3.49 Å |
Structure data | PDB-8uy1: PDB-8uy2: |
Chemicals | ChemComp-FAD: ChemComp-HOH: ChemComp-SAM: ChemComp-ACT: ChemComp-SO4: ChemComp-NA: ChemComp-GOL: |
Source |
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Keywords | OXIDOREDUCTASE / methylenetetrahydrofolate reductase / NADPH activity / oxidoreductase activity / acting on the CH-NH group of donors / NAD or NADP as acceptor cobalamin binding / one-carbon metabolism / OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |