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-Structure paper
Title | Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 1447-1459, Year 2024 |
Publish date | Sep 7, 2023 (structure data deposition date) |
Authors | Visser, M. / Papillon, J.P.N. / Luzzio, M. / LaMarche, M.J. / Fan, J. / Michael, W. / Wang, D. / Zhang, A. / Straub, C. / Mathieu, S. ...Visser, M. / Papillon, J.P.N. / Luzzio, M. / LaMarche, M.J. / Fan, J. / Michael, W. / Wang, D. / Zhang, A. / Straub, C. / Mathieu, S. / Kato, M. / Palermo, M. / Chen, C. / Ramsey, T. / Joud, C. / Barrett, R. / Vattay, A. / Guo, R. / Bric, A. / Chung, F. / Liang, G. / Romanowski, M.J. / Lam, J. / Thohan, S. / Atassi, F. / Wylie, A. / Cooke, V.G. |
External links | J. Med. Chem. / PubMed:38198520 |
Methods | X-ray diffraction |
Resolution | 2.48 - 2.82 Å |
Structure data | PDB-8u37: PDB-8uak: |
Chemicals | ChemComp-V5U: ChemComp-MG: ChemComp-HOH: ChemComp-W39: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR complex / Inhibitor / complex / Darovasertib / NVP-LXS196 / NVP-CJL037 / 8u37 |