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-Structure paper
Title | Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 9954-9971, Year 2023 |
Publish date | Apr 24, 2023 (structure data deposition date) |
Authors | Le, K. / Soth, M.J. / Cross, J.B. / Liu, G. / Ray, W.J. / Ma, J. / Goodwani, S.G. / Acton, P.J. / Buggia-Prevot, V. / Akkermans, O. ...Le, K. / Soth, M.J. / Cross, J.B. / Liu, G. / Ray, W.J. / Ma, J. / Goodwani, S.G. / Acton, P.J. / Buggia-Prevot, V. / Akkermans, O. / Barker, J. / Conner, M.L. / Jiang, Y. / Liu, Z. / McEwan, P. / Warner-Schmidt, J. / Xu, A. / Zebisch, M. / Heijnen, C.J. / Abrahams, B. / Jones, P. |
External links | J. Med. Chem. / PubMed:37436942 |
Methods | X-ray diffraction |
Resolution | 1.935 - 2.2 Å |
Structure data | PDB-8our: PDB-8ous: PDB-8out: |
Chemicals | ChemComp-W38: ChemComp-HOH: ChemComp-W3I: ChemComp-W3C: |
Source |
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Keywords | SIGNALING PROTEIN / DLK / KINASE / INHIBITOR / TRANSFERASE-INHIBITOR / M3K12 |