Entry | Database: PDB / ID: 8ous |
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Title | CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 19 |
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Components | Mitogen-activated protein kinase kinase kinase 12 |
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Keywords | SIGNALING PROTEIN / DLK / KINASE / INHIBITOR / TRANSFERASE-INHIBITOR / M3K12 |
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Function / homology | Function and homology information
mitogen-activated protein kinase kinase kinase / negative regulation of motor neuron apoptotic process / MAP kinase kinase kinase activity / JNK cascade / post-translational protein modification / protein serine/threonine kinase activator activity / protein autophosphorylation / growth cone / positive regulation of ERK1 and ERK2 cascade / protein kinase activity ...mitogen-activated protein kinase kinase kinase / negative regulation of motor neuron apoptotic process / MAP kinase kinase kinase activity / JNK cascade / post-translational protein modification / protein serine/threonine kinase activator activity / protein autophosphorylation / growth cone / positive regulation of ERK1 and ERK2 cascade / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / positive regulation of DNA-templated transcription / protein homodimerization activity / ATP binding / membrane / plasma membrane / cytosol / cytoplasmSimilarity search - Function Mitogen-activated protein kinase kinase kinase 12/13 / Mitogen-activated protein kinase kinase kinase 12 / : / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å |
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Authors | Zebisch, M. / McEwan, P.A. / Barker, J.J. / Cross, J.B. |
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Funding support | United States, 1items Organization | Grant number | Country |
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Alzheimers Drug Discovery Foundation (ADDF) | 20160903 | United States |
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Citation | Journal: J.Med.Chem. / Year: 2023 Title: Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. Authors: Le, K. / Soth, M.J. / Cross, J.B. / Liu, G. / Ray, W.J. / Ma, J. / Goodwani, S.G. / Acton, P.J. / Buggia-Prevot, V. / Akkermans, O. / Barker, J. / Conner, M.L. / Jiang, Y. / Liu, Z. / ...Authors: Le, K. / Soth, M.J. / Cross, J.B. / Liu, G. / Ray, W.J. / Ma, J. / Goodwani, S.G. / Acton, P.J. / Buggia-Prevot, V. / Akkermans, O. / Barker, J. / Conner, M.L. / Jiang, Y. / Liu, Z. / McEwan, P. / Warner-Schmidt, J. / Xu, A. / Zebisch, M. / Heijnen, C.J. / Abrahams, B. / Jones, P. |
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History | Deposition | Apr 24, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 26, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 9, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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Revision 1.2 | Jun 19, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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