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TitleCapsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait.
Journal, issue, pagesViruses, Vol. 14, Issue 10, Year 2022
Publish dateOct 9, 2022
AuthorsRenuk Lakshmanan / Mario Mietzsch / Alberto Jimenez Ybargollin / Paul Chipman / Xiaofeng Fu / Jianming Qiu / Maria Söderlund-Venermo / Robert McKenna /
PubMed AbstractParvoviruses are small, single-stranded DNA viruses with non-enveloped capsids. Determining the capsid structures provides a framework for annotating regions important to the viral life cycle. ...Parvoviruses are small, single-stranded DNA viruses with non-enveloped capsids. Determining the capsid structures provides a framework for annotating regions important to the viral life cycle. Aleutian mink disease virus (AMDV), a pathogen in minks, and human parvovirus 4 (PARV4), infecting humans, are parvoviruses belonging to the genera and , respectively. While Aleutian mink disease caused by AMDV is a major threat to mink farming, no clear clinical manifestations have been established following infection with PARV4 in humans. Here, the capsid structures of AMDV and PARV4 were determined via cryo-electron microscopy at 2.37 and 3.12 Å resolutions, respectively. Despite low amino acid sequence identities (10-30%) both viruses share the icosahedral nature of parvovirus capsids, with 60 viral proteins (VPs) assembling the capsid via two-, three-, and five-fold symmetry VP-related interactions, but display major structural variabilities in the surface loops when the capsid structures are superposed onto other parvoviruses. The capsid structures of AMDV and PARV4 will add to current knowledge of the structural platform for parvoviruses and permit future functional annotation of these viruses, which will help in understanding their infection mechanisms at a molecular level for the development of diagnostics and therapeutics.
External linksViruses / PubMed:36298773 / PubMed Central
MethodsEM (single particle)
Resolution2.37 - 3.18 Å
Structure data

28514

8ep2

EMDB-28514, PDB-8ep2:
The capsid structure of Aleutian Mink Disease Virus
Method: EM (single particle) / Resolution: 2.37 Å

EMDB-28515: Aleutian Mink Disease Virus VP2
Method: EM (single particle) / Resolution: 3.18 Å

28522

8ep9

EMDB-28522, PDB-8ep9:
The capsid structure of Human Parvovirus 4
Method: EM (single particle) / Resolution: 3.12 Å

Source
  • aleutian mink disease virus
  • human parvovirus 4
KeywordsVIRUS LIKE PARTICLE / Parvovirus; Capsid; AMDV; cryo-EM; Amdoparvovirus; Pathogen / Parvovirus / Capsid / PARV4 / Tetraparvovirus / Pathogen

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