National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
GM082946
米国
引用
ジャーナル: Viruses / 年: 2022 タイトル: Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait. 著者: Renuk Lakshmanan / Mario Mietzsch / Alberto Jimenez Ybargollin / Paul Chipman / Xiaofeng Fu / Jianming Qiu / Maria Söderlund-Venermo / Robert McKenna / 要旨: Parvoviruses are small, single-stranded DNA viruses with non-enveloped capsids. Determining the capsid structures provides a framework for annotating regions important to the viral life cycle. ...Parvoviruses are small, single-stranded DNA viruses with non-enveloped capsids. Determining the capsid structures provides a framework for annotating regions important to the viral life cycle. Aleutian mink disease virus (AMDV), a pathogen in minks, and human parvovirus 4 (PARV4), infecting humans, are parvoviruses belonging to the genera and , respectively. While Aleutian mink disease caused by AMDV is a major threat to mink farming, no clear clinical manifestations have been established following infection with PARV4 in humans. Here, the capsid structures of AMDV and PARV4 were determined via cryo-electron microscopy at 2.37 and 3.12 Å resolutions, respectively. Despite low amino acid sequence identities (10-30%) both viruses share the icosahedral nature of parvovirus capsids, with 60 viral proteins (VPs) assembling the capsid via two-, three-, and five-fold symmetry VP-related interactions, but display major structural variabilities in the surface loops when the capsid structures are superposed onto other parvoviruses. The capsid structures of AMDV and PARV4 will add to current knowledge of the structural platform for parvoviruses and permit future functional annotation of these viruses, which will help in understanding their infection mechanisms at a molecular level for the development of diagnostics and therapeutics.
履歴
登録
2022年10月5日
登録サイト: RCSB / 処理サイト: RCSB
改定 1.0
2022年11月9日
Provider: repository / タイプ: Initial release
改定 1.1
2024年6月19日
Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond
#200 - 2016年8月 正二十面体型ウイルスの準対称性 (Quasisymmetry in Icosahedral Viruses) 類似性 (1)
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集合体
登録構造単位
A: Human Parvovirus 4 B: Human Parvovirus 4 C: Human Parvovirus 4 D: Human Parvovirus 4 E: Human Parvovirus 4 F: Human Parvovirus 4 G: Human Parvovirus 4 H: Human Parvovirus 4 I: Human Parvovirus 4 J: Human Parvovirus 4 K: Human Parvovirus 4 L: Human Parvovirus 4 M: Human Parvovirus 4 N: Human Parvovirus 4 O: Human Parvovirus 4 P: Human Parvovirus 4 Q: Human Parvovirus 4 R: Human Parvovirus 4 S: Human Parvovirus 4 T: Human Parvovirus 4 U: Human Parvovirus 4 V: Human Parvovirus 4 W: Human Parvovirus 4 X: Human Parvovirus 4 Y: Human Parvovirus 4 Z: Human Parvovirus 4 a: Human Parvovirus 4 b: Human Parvovirus 4 c: Human Parvovirus 4 d: Human Parvovirus 4 e: Human Parvovirus 4 f: Human Parvovirus 4 g: Human Parvovirus 4 h: Human Parvovirus 4 i: Human Parvovirus 4 j: Human Parvovirus 4 k: Human Parvovirus 4 l: Human Parvovirus 4 m: Human Parvovirus 4 n: Human Parvovirus 4 o: Human Parvovirus 4 p: Human Parvovirus 4 q: Human Parvovirus 4 r: Human Parvovirus 4 s: Human Parvovirus 4 t: Human Parvovirus 4 u: Human Parvovirus 4 v: Human Parvovirus 4 w: Human Parvovirus 4 x: Human Parvovirus 4 y: Human Parvovirus 4 z: Human Parvovirus 4 1: Human Parvovirus 4 2: Human Parvovirus 4 3: Human Parvovirus 4 4: Human Parvovirus 4 5: Human Parvovirus 4 6: Human Parvovirus 4 7: Human Parvovirus 4 8: Human Parvovirus 4