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TitlePlaying beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
Journal, issue, pagesto be published
Publish dateOct 2, 2022 (structure data deposition date)
AuthorsD'Amico Gonzalez, G. / Handelsman, J. / Centron, D. / Gutkind, G. / Klinke, S. / Power, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 - 2.35 Å
Structure data

PDB-8eo5:
Crystal structure of the class A beta-lactamase precursor LRA-5 from an Alaskan soil metagenome at 1.8 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8eo6:
Crystal structure of metagenomic class A beta-lactamase precursor LRA-5 in complex with ceftazidime at 2.35 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-8eo7:
Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-CAZ:
ACYLATED CEFTAZIDIME

Source
  • uncultured soil bacterium (environmental samples)
KeywordsANTIMICROBIAL PROTEIN / beta-lactamase precursor / environmental resistome / soil metagenome / ceftazidime / oxyimino-cephalosporin / mutant

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