+Search query
-Structure paper
Title | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 65, Page 13198-13215, Year 2022 |
Publish date | Aug 13, 2022 (structure data deposition date) |
Authors | Bubenik, M. / Mader, P. / Mochirian, P. / Vallee, F. / Clark, J. / Truchon, J.F. / Perryman, A.L. / Pau, V. / Kurinov, I. / Zahn, K.E. ...Bubenik, M. / Mader, P. / Mochirian, P. / Vallee, F. / Clark, J. / Truchon, J.F. / Perryman, A.L. / Pau, V. / Kurinov, I. / Zahn, K.E. / Leclaire, M.E. / Papp, R. / Mathieu, M.C. / Hamel, M. / Duffy, N.M. / Godbout, C. / Casas-Selves, M. / Falgueyret, J.P. / Baruah, P.S. / Nicolas, O. / Stocco, R. / Poirier, H. / Martino, G. / Fortin, A.B. / Roulston, A. / Chefson, A. / Dorich, S. / St-Onge, M. / Patel, P. / Pellerin, C. / Ciblat, S. / Pinter, T. / Barabe, F. / El Bakkouri, M. / Parikh, P. / Gervais, C. / Sfeir, A. / Mamane, Y. / Morris, S.J. / Black, W.C. / Sicheri, F. / Gallant, M. |
External links | J. Med. Chem. / PubMed:36126059 |
Methods | X-ray diffraction |
Resolution | 2.34 - 2.59 Å |
Structure data | PDB-8e23: PDB-8e24: |
Chemicals | ChemComp-MG: ChemComp-DG3: ChemComp-UAF: ChemComp-HOH: ChemComp-UA6: |
Source |
|
Keywords | DNA BINDING PROTEIN/DNA / DNA polymerase theta / inhibitor / allosteric / complex / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex |