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-Structure paper
Title | Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 71, Page 116949-116949, Year 2022 |
Publish date | Jul 1, 2022 (structure data deposition date) |
Authors | Imaizumi, T. / Akaiwa, M. / Abe, T. / Nigawara, T. / Koike, T. / Satake, Y. / Watanabe, K. / Kaneko, O. / Amano, Y. / Mori, K. ...Imaizumi, T. / Akaiwa, M. / Abe, T. / Nigawara, T. / Koike, T. / Satake, Y. / Watanabe, K. / Kaneko, O. / Amano, Y. / Mori, K. / Yamanaka, Y. / Nagashima, T. / Shimazaki, M. / Kuramoto, K. |
External links | Bioorg. Med. Chem. / PubMed:35926326 |
Methods | X-ray diffraction |
Resolution | 1.79 - 1.8 Å |
Structure data | PDB-7ycc: PDB-7yce: |
Chemicals | ChemComp-GDP: ChemComp-MG: ChemComp-IQC: ChemComp-HOH: ChemComp-SO4: ChemComp-IQN: |
Source |
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Keywords | ONCOPROTEIN/INHIBITOR / ONCOPROTEIN-inhibitor complex |