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TitleStructural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan.
Journal, issue, pagesMol. Pharmacol., Year 2022
Publish dateDec 7, 2021 (structure data deposition date)
AuthorsRen, X. / Diao, X. / Zhuang, J. / Wu, D.
External linksMol. Pharmacol. / PubMed:36167425
MethodsX-ray diffraction
Resolution2.754 Å
Structure data

PDB-7w80:
Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan
Method: X-RAY DIFFRACTION / Resolution: 2.754 Å

Chemicals

ChemComp-72Q:
3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile / medication, anticancer*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTRANSCRIPTION / Hypoxia-inducible factor 2 / HIF-2alpha / ARNT

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