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-Structure paper
Title | Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14-Demethylase as a Key Drug Target |
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Journal, issue, pages | J. Med. Chem., Year 2024 |
Publish date | May 3, 2022 (structure data deposition date) |
Authors | Hargrove, T.Y. / Lamb, D.C. / Wawrzak, Z. / Hull, M. / Kelly, S.L. / Guengerich, F.P. / Lepesheva, G.I. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.29 Å |
Structure data | PDB-7uwp: PDB-8ekt: |
Chemicals | ChemComp-HEM: ChemComp-LMT: ChemComp-HOH: ChemComp-VT1: |
Source |
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Keywords | OXIDOREDUCTASE / CYTOCHROME P450 / CYP51 / STEROL 14 ALPHA- DEMETHYLASE / sterol biosynthesis / OXIDOREDUCTASE/INHIBITOR / sterol 14alpha-demethylase / OXIDOREDUCTASE-INHIBITOR complex |