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Title | Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity. |
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Journal, issue, pages | J. Mol. Biol., Vol. 434, Page 167720-167720, Year 2022 |
Publish date | Jul 4, 2021 (structure data deposition date) |
![]() | Tsika, A.C. / Gallo, A. / Fourkiotis, N.K. / Argyriou, A.I. / Sreeramulu, S. / Lohr, F. / Rogov, V.V. / Richter, C. / Linhard, V. / Gande, S.L. ...Tsika, A.C. / Gallo, A. / Fourkiotis, N.K. / Argyriou, A.I. / Sreeramulu, S. / Lohr, F. / Rogov, V.V. / Richter, C. / Linhard, V. / Gande, S.L. / Altincekic, N. / Krishnathas, R. / Elamri, I. / Schwalbe, H. / Wollenhaupt, J. / Weiss, M.S. / Spyroulias, G.A. |
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Methods | NMR (solution) / X-ray diffraction |
Resolution | 1.72 Å |
Structure data | ![]() PDB-7p27: ![]() PDB-7qg7: |
Chemicals | ![]() ChemComp-U08: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
Source |
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![]() | VIRAL PROTEIN / CHIKV / macro domain / viral replication / ADP-ribose / NSP3 / Macrodomain / SARS-COV-2 / Remdesivir / GS-441524 / COVID-19 / Drug Discovery |