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-Structure paper
Title | Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. |
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Journal, issue, pages | Cell Rep, Vol. 37, Page 110129-110129, Year 2021 |
Publish date | Oct 18, 2021 (structure data deposition date) |
Authors | Marek, M. / Ramos-Morales, E. / Picchi-Constante, G.F.A. / Bayer, T. / Norstrom, C. / Herp, D. / Sales-Junior, P.A. / Guerra-Slompo, E.P. / Hausmann, K. / Chakrabarti, A. ...Marek, M. / Ramos-Morales, E. / Picchi-Constante, G.F.A. / Bayer, T. / Norstrom, C. / Herp, D. / Sales-Junior, P.A. / Guerra-Slompo, E.P. / Hausmann, K. / Chakrabarti, A. / Shaik, T.B. / Merz, A. / Troesch, E. / Schmidtkunz, K. / Goldenberg, S. / Pierce, R.J. / Mourao, M.M. / Jung, M. / Schultz, J. / Sippl, W. / Zanchin, N.I.T. / Romier, C. |
External links | Cell Rep / PubMed:34936867 |
Methods | X-ray diffraction |
Resolution | 1.75 - 2.3 Å |
Structure data | PDB-7q1b: PDB-7q1c: |
Chemicals | ChemComp-ZN: ChemComp-K: ChemComp-GOK: ChemComp-GOL: ChemComp-HOH: ChemComp-T56: |
Source |
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Keywords | HYDROLASE / Epigenetics / Trypanosoma cruzi / Histone deacetylase / DAC2 / Pathogen |