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-Structure paper
Title | The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement. |
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Journal, issue, pages | Nat Commun, Vol. 13, Page 6073-6073, Year 2022 |
Publish date | Oct 18, 2021 (structure data deposition date) |
Authors | Brinkhaus, M. / Pannecoucke, E. / van der Kooi, E.J. / Bentlage, A.E.H. / Derksen, N.I.L. / Andries, J. / Balbino, B. / Sips, M. / Ulrichts, P. / Verheesen, P. ...Brinkhaus, M. / Pannecoucke, E. / van der Kooi, E.J. / Bentlage, A.E.H. / Derksen, N.I.L. / Andries, J. / Balbino, B. / Sips, M. / Ulrichts, P. / Verheesen, P. / de Haard, H. / Rispens, T. / Savvides, S.N. / Vidarsson, G. |
External links | Nat Commun / PubMed:36241613 |
Methods | X-ray diffraction |
Resolution | 2.1 - 3.301 Å |
Structure data | PDB-7q15: PDB-7q3p: |
Chemicals | ChemComp-NAG: ChemComp-BMA: ChemComp-MAN: ChemComp-FUC: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / Neonatal Fc Receptor FcRn / FcRn / Fc / IgG1-Fc-MST-HN / efgartigimod / ARGX-113 / FcRn-binding protein |