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-Structure paper
Title | Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. |
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Journal, issue, pages | Comput Struct Biotechnol J, Vol. 20, Page 443-458, Year 2022 |
Publish date | Mar 10, 2021 (structure data deposition date) |
Authors | Margreiter, M.A. / Witzenberger, M. / Wasser, Y. / Davydova, E. / Janowski, R. / Metz, J. / Habib, P. / Sahnoun, S.E.M. / Sobisch, C. / Poma, B. ...Margreiter, M.A. / Witzenberger, M. / Wasser, Y. / Davydova, E. / Janowski, R. / Metz, J. / Habib, P. / Sahnoun, S.E.M. / Sobisch, C. / Poma, B. / Palomino-Hernandez, O. / Wagner, M. / Carell, T. / Jon Shah, N. / Schulz, J.B. / Niessing, D. / Voigt, A. / Rossetti, G. |
External links | Comput Struct Biotechnol J / PubMed:35070167 |
Methods | X-ray diffraction |
Resolution | 1.23 - 2.016 Å |
Structure data | PDB-7ntn: PDB-7nto: |
Chemicals | ChemComp-SO4: ChemComp-CL: ChemComp-NA: ChemComp-HOH: ChemComp-EDO: |
Source |
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Keywords | TRANSFERASE / tRNA binding / methyltransferase / TRMT2a / polyQ aggregation |