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TitleGABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Journal, issue, pagesSci Adv, Vol. 7, Page eabj2485-eabj2485, Year 2021
Publish dateFeb 18, 2021 (structure data deposition date)
AuthorsGoodwin, J.M. / Walkup 4th, W.G. / Hooper, K. / Li, T. / Kishi-Itakura, C. / Ng, A. / Lehmberg, T. / Jha, A. / Kommineni, S. / Fletcher, K. ...Goodwin, J.M. / Walkup 4th, W.G. / Hooper, K. / Li, T. / Kishi-Itakura, C. / Ng, A. / Lehmberg, T. / Jha, A. / Kommineni, S. / Fletcher, K. / Garcia-Fortanet, J. / Fan, Y. / Tang, Q. / Wei, M. / Agrawal, A. / Budhe, S.R. / Rouduri, S.R. / Baird, D. / Saunders, J. / Kiselar, J. / Chance, M.R. / Ballabio, A. / Appleton, B.A. / Brumell, J.H. / Florey, O. / Murphy, L.O.
External linksSci Adv / PubMed:34597140
MethodsX-ray diffraction
Resolution1.8 - 3.05 Å
Structure data

PDB-7lsw:
Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-7lt6:
Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / AUTOPHAGY / ATG8 / LIR

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