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-Structure paper
Title | Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 12, Page 1678-1688, Year 2021 |
Publish date | Sep 15, 2020 (structure data deposition date) |
Authors | Li, D. / Zhang, H. / Lyons, T.W. / Lu, M. / Achab, A. / Pu, Q. / Childers, M. / Mitcheltree, M.J. / Wang, J. / Martinot, T.A. ...Li, D. / Zhang, H. / Lyons, T.W. / Lu, M. / Achab, A. / Pu, Q. / Childers, M. / Mitcheltree, M.J. / Wang, J. / Martinot, T.A. / McMinn, S.E. / Sloman, D.L. / Palani, A. / Beard, A. / Nogle, L. / Gathiaka, S. / Sauri, J. / Kim, H.Y. / Adpressa, D. / Spacciapoli, P. / Miller, J.R. / Palte, R.L. / Lesburg, C.A. / Cumming, J. / Fischer, C. |
External links | Acs Med. Chem. Lett. / PubMed:34795856 |
Methods | X-ray diffraction |
Resolution | 1.65 - 2.27 Å |
Structure data | PDB-7k4g: PDB-7k4h: PDB-7k4i: PDB-7k4j: PDB-7k4k: |
Chemicals | ChemComp-MN: ChemComp-VUV: ChemComp-HOH: ChemComp-VV4: ChemComp-VUY: ChemComp-VV1: ChemComp-VUS: |
Source |
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Keywords | HYDROLASE/HYDROLASE inhibitor / Arginase / hydrolase / arginine / urea cycle / inhibitor / HYDROLASE-HYDROLASE inhibitor complex |