+Search query
-Structure paper
Title | Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem., Vol. 52, Page 116500-116500, Year 2021 |
Publish date | Jul 8, 2021 (structure data deposition date) |
Authors | Kori, S. / Shibahashi, Y. / Ekimoto, T. / Nishiyama, A. / Yoshimi, S. / Yamaguchi, K. / Nagatoishi, S. / Ohta, M. / Tsumoto, K. / Nakanishi, M. ...Kori, S. / Shibahashi, Y. / Ekimoto, T. / Nishiyama, A. / Yoshimi, S. / Yamaguchi, K. / Nagatoishi, S. / Ohta, M. / Tsumoto, K. / Nakanishi, M. / Defossez, P.A. / Ikeguchi, M. / Arita, K. |
External links | Bioorg. Med. Chem. / PubMed:34801826 |
Methods | X-ray diffraction |
Resolution | 1.45 Å |
Structure data | PDB-7fb7: |
Chemicals | ChemComp-MPD: ChemComp-8NF: ChemComp-DMS: ChemComp-SO4: ChemComp-HOH: |
Source |
|
Keywords | DNA BINDING PROTEIN / DNA methylation / histone modification / inhibitor |