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-Structure paper
Title | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action. |
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Journal, issue, pages | Mabs, Vol. 12, Page 1801230-1801230 |
Publish date | Sep 6, 2019 (structure data deposition date) |
![]() | Austin, M. / Burschowsky, D. / Chan, D.T.Y. / Jenkinson, L. / Haynes, S. / Diamandakis, A. / Seewooruthun, C. / Addyman, A. / Fiedler, S. / Ryman, S. ...Austin, M. / Burschowsky, D. / Chan, D.T.Y. / Jenkinson, L. / Haynes, S. / Diamandakis, A. / Seewooruthun, C. / Addyman, A. / Fiedler, S. / Ryman, S. / Whitehouse, J. / Slater, L.H. / Hadjinicolaou, A.V. / Gileadi, U. / Gowans, E. / Shibata, Y. / Barnard, M. / Kaserer, T. / Sharma, P. / Luheshi, N.M. / Wilkinson, R.W. / Vaughan, T.J. / Holt, S.V. / Cerundolo, V. / Carr, M.D. / Groves, M.A.T. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 2.9 Å |
Structure data | ![]() PDB-6srv: ![]() PDB-6srx: ![]() PDB-6ss0: ![]() PDB-6ss2: ![]() PDB-6ss4: ![]() PDB-6tul: |
Chemicals | ![]() ChemComp-CL: ![]() ChemComp-EDO: ![]() ChemComp-PEG: ![]() ChemComp-TRS: ![]() ChemComp-HOH: ![]() ChemComp-ACT: ![]() ChemComp-SIN: ![]() ChemComp-PGE: ![]() ChemComp-GOL: ![]() ChemComp-MN: ![]() ChemComp-SO4: ![]() ChemComp-PO4: ![]() ChemComp-PG4: ![]() ChemComp-P6G: ![]() ChemComp-MLT: |
Source |
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![]() | PROTEIN BINDING / arginase-2 inhibitor / IgG / antigen-binding fragment |