+Search query
-Structure paper
Title | Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. |
---|---|
Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 58, Page 18823-18829, Year 2019 |
Publish date | Jul 15, 2019 (structure data deposition date) |
Authors | Quambusch, L. / Landel, I. / Depta, L. / Weisner, J. / Uhlenbrock, N. / Muller, M.P. / Glanemann, F. / Althoff, K. / Siveke, J.T. / Rauh, D. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:31584233 |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.6 Å |
Structure data | PDB-6s9w: PDB-6s9x: |
Chemicals | ChemComp-L1Z: ChemComp-HOH: ChemComp-L1W: |
Source |
|
Keywords | TRANSFERASE / Akt1 / Akt2 / Akt3 / borussertib / covalent-allosteric |