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TitleCryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
Journal, issue, pagesNat Commun, Vol. 10, Issue 1, Page 1181, Year 2019
Publish dateMar 12, 2019
AuthorsEmilie Vassal-Stermann / Gregory Effantin / Chloe Zubieta / Wim Burmeister / Frédéric Iseni / Hongjie Wang / André Lieber / Guy Schoehn / Pascal Fender /
PubMed AbstractAttachment of human adenovirus (HAd) to the host cell is a critical step of infection. Initial attachment occurs via the adenoviral fibre knob protein and a cellular receptor. Here we report the cryo- ...Attachment of human adenovirus (HAd) to the host cell is a critical step of infection. Initial attachment occurs via the adenoviral fibre knob protein and a cellular receptor. Here we report the cryo-electron microscopy (cryo-EM) structure of a <100 kDa non-symmetrical complex comprising the trimeric HAd type 3 fibre knob (HAd3K) and human desmoglein 2 (DSG2). The structure reveals a unique stoichiometry of 1:1 and 2:1 (DSG2: knob trimer) not previously observed for other HAd-receptor complexes. We demonstrate that mutating Asp261 in the fibre knob is sufficient to totally abolish receptor binding. These data shed new light on adenovirus infection strategies and provide insights for adenoviral vector development and structure-based design.
External linksNat Commun / PubMed:30862836 / PubMed Central
MethodsEM (single particle)
Resolution3.5 - 3.8 Å
Structure data

4608

6qnt

EMDB-4608, PDB-6qnt:
Human Adenovirus type 3 fiber knob in complex with one copy of Desmoglein-2
Method: EM (single particle) / Resolution: 3.5 Å

4609

6qnu

EMDB-4609, PDB-6qnu:
Human Adenovirus type 3 fiber knob in complex with two copies of Desmoglein-2
Method: EM (single particle) / Resolution: 3.8 Å

Source
  • human adenovirus b serotype 3
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / virus receptor / adenovirus / vector

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