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-Structure paper
Title | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 177, Page 188-197, Year 2019 |
Publish date | Mar 27, 2019 (structure data deposition date) |
Authors | Angeli, A. / Di Cesare Mannelli, L. / Ghelardini, C. / Peat, T.S. / Bartolucci, G. / Menicatti, M. / Carta, F. / Supuran, C.T. |
External links | Eur. J. Med. Chem. / PubMed:31136893 |
Methods | X-ray diffraction |
Resolution | 1.3 - 1.45 Å |
Structure data | PDB-6odz: PDB-6oe0: PDB-6oe1: |
Chemicals | ChemComp-ZN: ChemComp-M8J: ChemComp-GOL: ChemComp-HOH: ChemComp-M8S: ChemComp-M8V: ChemComp-SO4: |
Source |
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Keywords | LYASE/LYASE INHIBITOR / carbonic anhydrase inhibitors / metalloenzymes / organoselenium / LYASE-LYASE INHIBITOR complex |