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Title | Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. |
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Journal, issue, pages | Acs Omega, Vol. 4, Page 10056-10069, Year 2019 |
Publish date | Feb 10, 2019 (structure data deposition date) |
Authors | Toulouse, J.L. / Yachnin, B.J. / Ruediger, E.H. / Deon, D. / Gagnon, M. / Saint-Jacques, K. / Ebert, M.C.C.J.C. / Forge, D. / Bastien, D. / Colin, D.Y. ...Toulouse, J.L. / Yachnin, B.J. / Ruediger, E.H. / Deon, D. / Gagnon, M. / Saint-Jacques, K. / Ebert, M.C.C.J.C. / Forge, D. / Bastien, D. / Colin, D.Y. / Vanden Eynde, J.J. / Marinier, A. / Berghuis, A.M. / Pelletier, J.N. |
External links | Acs Omega / PubMed:31460098 |
Methods | X-ray diffraction |
Resolution | 1.4 - 1.75 Å |
Structure data | PDB-6nxz: PDB-6ny0: |
Chemicals | ChemComp-D49: ChemComp-MRD: ChemComp-PO4: ChemComp-HOH: ChemComp-LBA: |
Source |
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Keywords | OXIDOREDUCTASE / antibiotic resistance; selective inhibitor; R67 DHFR; SH3-like barrel / ANTIBIOTIC |