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Structure paper

TitleDisulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 5105-5120, Year 2019
Publish dateDec 18, 2017 (structure data deposition date)
AuthorsCohen, I. / Coban, M. / Shahar, A. / Sankaran, B. / Hockla, A. / Lacham, S. / Caulfield, T.R. / Radisky, E.S. / Papo, N.
External linksJ. Biol. Chem. / PubMed:30700553
MethodsX-ray diffraction
Resolution1.497 - 1.98 Å
Structure data

PDB-6bx8:
Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-6har:
Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
Method: X-RAY DIFFRACTION / Resolution: 1.497 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Hydrolase Inhibitor / PROTEIN FIBRIL / PRSS3 / Mesotrypsin / Serine protease / Kunitz type inhibitor / APPI

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