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-Structure paper
Title | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 3380-3385, Year 2018 |
Publish date | Oct 24, 2017 (structure data deposition date) |
Authors | Vogeli, B. / Engilberge, S. / Girard, E. / Riobe, F. / Maury, O. / Erb, T.J. / Shima, S. / Wagner, T. |
External links | Proc. Natl. Acad. Sci. U.S.A. / PubMed:29531083 |
Methods | X-ray diffraction |
Resolution | 2.75 - 2.95 Å |
Structure data | PDB-6esq: PDB-6et9: |
Chemicals | ChemComp-COA: ChemComp-K: ChemComp-ZN: ChemComp-CL: ChemComp-NA: ChemComp-HOH: ChemComp-TRS: ChemComp-MG: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / Isoprenoid synthesis / enzymatic channeling / mevalonate production / archaea / lipid biosynthesis / multi-enzymatic complex / scaffold protein / DUF35 family |