+Search query
-Structure paper
Title | Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 61, Page 2384-2409, Year 2018 |
Publish date | Jan 9, 2018 (structure data deposition date) |
Authors | Yoshikawa, M. / Saitoh, M. / Katoh, T. / Seki, T. / Bigi, S.V. / Shimizu, Y. / Ishii, T. / Okai, T. / Kuno, M. / Hattori, H. ...Yoshikawa, M. / Saitoh, M. / Katoh, T. / Seki, T. / Bigi, S.V. / Shimizu, Y. / Ishii, T. / Okai, T. / Kuno, M. / Hattori, H. / Watanabe, E. / Saikatendu, K.S. / Zou, H. / Nakakariya, M. / Tatamiya, T. / Nakada, Y. / Yogo, T. |
External links | J. Med. Chem. / PubMed:29485864 |
Methods | X-ray diffraction |
Resolution | 2.52 - 2.6 Å |
Structure data | PDB-6c3e: PDB-6c4d: |
Chemicals | ChemComp-EJY: ChemComp-HOH: ChemComp-EJP: |
Source |
|
Keywords | Transferase/Transferase Inhibitor / HUMAN RIP1 KINASE / CELL CYCLE / Transferase-Transferase Inhibitor complex / HUMAN RIPK1 KINASE |