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TitleAtomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.
Journal, issue, pagesNat Commun, Vol. 8, Issue 1, Page 505, Year 2017
Publish dateSep 11, 2017
AuthorsLongfa Xu / Qingbing Zheng / Shaowei Li / Maozhou He / Yangtao Wu / Yongchao Li / Rui Zhu / Hai Yu / Qiyang Hong / Jie Jiang / Zizhen Li / Shuxuan Li / Huan Zhao / Lisheng Yang / Wangheng Hou / Wei Wang / Xiangzhong Ye / Jun Zhang / Timothy S Baker / Tong Cheng / Z Hong Zhou / Xiaodong Yan / Ningshao Xia /
PubMed AbstractCoxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the ...Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identical atomic capsid structures resembling the uncoating intermediates of other enteroviruses. Our near-atomic resolution structure of CVA6 A-particle complexed with a neutralizing antibody maps an immune-dominant neutralizing epitope to the surface loops of VP1. The structure-guided cell-based inhibition studies further demonstrate that these loops could serve as excellent targets for designing anti-CVA6 vaccines.Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.
External linksNat Commun / PubMed:28894095 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.8 Å
Structure data

6751

5xs4

EMDB-6751, PDB-5xs4:
Structure of Coxsackievirus A6 (CVA6) virus A-particle
Method: EM (single particle) / Resolution: 3.1 Å

6752

5xs5

EMDB-6752, PDB-5xs5:
Structure of Coxsackievirus A6 (CVA6) virus procapsid particle
Method: EM (single particle) / Resolution: 3.3 Å

6757

5xs7

EMDB-6757, PDB-5xs7:
Structure of Coxsackievirus A6 (CVA6) virus A-particle in complex with the neutralizing antibody fragment 1D5
Method: EM (single particle) / Resolution: 3.8 Å

Source
  • coxsackievirus a6
  • mus musculus (house mouse)
KeywordsVIRUS / Coxsackievirus A6 / A-particle / icosahedral / procapsid / Immune-complex

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