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-Structure paper
Title | A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. |
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Journal, issue, pages | Sci Rep, Vol. 9, Page 15930-15930, Year 2019 |
Publish date | Mar 16, 2017 (structure data deposition date) |
![]() | Sharma, P. / Mahen, R. / Rossmann, M. / Stokes, J.E. / Hardwick, B. / Huggins, D.J. / Emery, A. / Kunciw, D.L. / Hyvonen, M. / Spring, D.R. ...Sharma, P. / Mahen, R. / Rossmann, M. / Stokes, J.E. / Hardwick, B. / Huggins, D.J. / Emery, A. / Kunciw, D.L. / Hyvonen, M. / Spring, D.R. / McKenzie, G.J. / Venkitaraman, A.R. |
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Methods | X-ray diffraction |
Resolution | 1.785 - 2.02 Å |
Structure data | ![]() PDB-5nfu: ![]() PDB-5nje: ![]() PDB-5nmm: ![]() PDB-5nn1: ![]() PDB-5nn2: |
Chemicals | ![]() ChemComp-HOH: ![]() ChemComp-8Z5: ![]() ChemComp-Z24: |
Source |
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![]() | TRANSFERASE / PLK1 / PBD1 / mitosis / small molecule |