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TitleVaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.
Journal, issue, pagesCell, Vol. 166, Page 609-623, Year 2016
Publish dateMay 31, 2016 (structure data deposition date)
AuthorsJoyce, M.G. / Wheatley, A.K. / Thomas, P.V. / Chuang, G.Y. / Soto, C. / Bailer, R.T. / Druz, A. / Georgiev, I.S. / Gillespie, R.A. / Kanekiyo, M. ...Joyce, M.G. / Wheatley, A.K. / Thomas, P.V. / Chuang, G.Y. / Soto, C. / Bailer, R.T. / Druz, A. / Georgiev, I.S. / Gillespie, R.A. / Kanekiyo, M. / Kong, W.P. / Leung, K. / Narpala, S.N. / Prabhakaran, M.S. / Yang, E.S. / Zhang, B. / Zhang, Y. / Asokan, M. / Boyington, J.C. / Bylund, T. / Darko, S. / Lees, C.R. / Ransier, A. / Shen, C.H. / Wang, L. / Whittle, J.R. / Wu, X. / Yassine, H.M. / Santos, C. / Matsuoka, Y. / Tsybovsky, Y. / Baxa, U. / Mullikin, J.C. / Subbarao, K. / Douek, D.C. / Graham, B.S. / Koup, R.A. / Ledgerwood, J.E. / Roederer, M. / Shapiro, L. / Kwong, P.D. / Mascola, J.R. / McDermott, A.B.
External linksCell / PubMed:27453470
MethodsX-ray diffraction
Resolution1.904 - 3.514 Å
Structure data

PDB-5k9j:
Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 isolated following H5 immunization.
Method: X-RAY DIFFRACTION / Resolution: 1.904 Å

PDB-5k9k:
Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 in complex with Hemagglutinin Hong Kong 1968.
Method: X-RAY DIFFRACTION / Resolution: 2.97 Å

PDB-5k9o:
Crystal structure of multidonor HV1-18+HD3-9 class broadly neutralizing Influenza A antibody 31.b.09 in complex with Hemagglutinin H1 A/California/04/2009
Method: X-RAY DIFFRACTION / Resolution: 3.387 Å

PDB-5k9q:
Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 2.503 Å

PDB-5kan:
Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 2.785 Å

PDB-5kaq:
Crystal structure of broadly neutralizing Influenza A antibody 31.a.83 in complex with Hemagglutinin Hong Kong 1968.
Method: X-RAY DIFFRACTION / Resolution: 3.514 Å

Chemicals

ChemComp-15P:
POLYETHYLENE GLYCOL (N=34) / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • influenza a virus (strain a/hong kong/1/1968 h3n2)
  • influenza a virus (strain swl a/california/04/2009 h1n1)
  • influenza a virus
  • influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2))
KeywordsIMMUNE SYSTEM / Influenza / multidonor / H5 / universal influenza vaccine / HV1-18 / HV1-18 (QxxV)

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