+Search query
-Structure paper
Title | Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). |
---|---|
Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 113, Page 9274-9279, Year 2016 |
Publish date | Mar 29, 2016 (structure data deposition date) |
Authors | Salie, Z.L. / Kirby, K.A. / Michailidis, E. / Marchand, B. / Singh, K. / Rohan, L.C. / Kodama, E.N. / Mitsuya, H. / Parniak, M.A. / Sarafianos, S.G. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:27489345 |
Methods | X-ray diffraction |
Resolution | 2.432 - 2.896 Å |
Structure data | PDB-5j2m: PDB-5j2n: PDB-5j2p: PDB-5j2q: |
Chemicals | ChemComp-MG: ChemComp-6FN: ChemComp-HOH: ChemComp-6FM: |
Source |
|
Keywords | transferase/dna / HIV-1 / reverse transcriptase / RT / DNA / double stranded DNA / dsDNA / EFdA / 4'-ethynyl-2-fluoro-2'-deoxyadenosine / EFdA-triphosphate / EFdA-TP / inhibitors / NRTI / TDRTI / translocation defective / transferase-dna complex / EFdA-monophosphate / EFdA-MP / pre-translocation / N site / P site / post-translocation / mismatch |