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-Structure paper
Title | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 7, Page 531-536, Year 2016 |
Publish date | Feb 18, 2016 (structure data deposition date) |
![]() | Taylor, A.M. / Cote, A. / Hewitt, M.C. / Pastor, R. / Leblanc, Y. / Nasveschuk, C.G. / Romero, F.A. / Crawford, T.D. / Cantone, N. / Jayaram, H. ...Taylor, A.M. / Cote, A. / Hewitt, M.C. / Pastor, R. / Leblanc, Y. / Nasveschuk, C.G. / Romero, F.A. / Crawford, T.D. / Cantone, N. / Jayaram, H. / Setser, J. / Murray, J. / Beresini, M.H. / de Leon Boenig, G. / Chen, Z. / Conery, A.R. / Cummings, R.T. / Dakin, L.A. / Flynn, E.M. / Huang, O.W. / Kaufman, S. / Keller, P.J. / Kiefer, J.R. / Lai, T. / Li, Y. / Liao, J. / Liu, W. / Lu, H. / Pardo, E. / Tsui, V. / Wang, J. / Wang, Y. / Xu, Z. / Yan, F. / Yu, D. / Zawadzke, L. / Zhu, X. / Sims, R.J. / Cochran, A.G. / Bellon, S. / Audia, J.E. / Magnuson, S. / Albrecht, B.K. |
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Methods | X-ray diffraction |
Resolution | 1.05 - 1.5218 Å |
Structure data | ![]() PDB-5i83: ![]() PDB-5i86: ![]() PDB-5i89: ![]() PDB-5i8b: ![]() PDB-5i8g: |
Chemicals | ![]() ChemComp-SCN: ![]() ChemComp-68Y: ![]() ChemComp-HOH: ![]() ChemComp-EDO: ![]() ChemComp-69A: ![]() ChemComp-ACT: ![]() ChemComp-CA: ![]() ChemComp-69B: ![]() ChemComp-ZN: ![]() ChemComp-69F: ![]() ChemComp-B3P: ![]() ChemComp-NA: ![]() ChemComp-PEG: ![]() ChemComp-69E: |
Source |
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![]() | PROTEIN BINDING/INHIBITOR / bromodomain inhibitor / PROTEIN BINDING-INHIBITOR complex / Transcription/Protein Binding / CREBBP / bromodomain / epigenetics / structure-based drug design / Transcription-Protein Binding complex |