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-Structure paper
Title | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. |
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Journal, issue, pages | Cancer Cell, Vol. 29, Page 477-493, Year 2016 |
Publish date | Jan 11, 2016 (structure data deposition date) |
Authors | Foster, S.A. / Whalen, D.M. / Ozen, A. / Wongchenko, M.J. / Yin, J. / Yen, I. / Schaefer, G. / Mayfield, J.D. / Chmielecki, J. / Stephens, P.J. ...Foster, S.A. / Whalen, D.M. / Ozen, A. / Wongchenko, M.J. / Yin, J. / Yen, I. / Schaefer, G. / Mayfield, J.D. / Chmielecki, J. / Stephens, P.J. / Albacker, L.A. / Yan, Y. / Song, K. / Hatzivassiliou, G. / Eigenbrot, C. / Yu, C. / Shaw, A.S. / Manning, G. / Skelton, N.J. / Hymowitz, S.G. / Malek, S. |
External links | Cancer Cell / PubMed:26996308 |
Methods | X-ray diffraction |
Resolution | 2.5 - 3 Å |
Structure data | PDB-5hi2: PDB-5hib: PDB-5hic: PDB-5hid: PDB-5hie: |
Chemicals | ChemComp-BAX: ChemComp-HOH: ChemComp-63M: ChemComp-SO4: ChemComp-63N: ChemComp-B1E: ChemComp-PEG: ChemComp-P06: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex / protein kinase / inhibitor |