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-Structure paper
Title | Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 5381-5394, Year 2014 |
Publish date | Feb 10, 2014 (structure data deposition date) |
![]() | Deng, X. / Kokkonda, S. / El Mazouni, F. / White, J. / Burrows, J.N. / Kaminsky, W. / Charman, S.A. / Matthews, D. / Rathod, P.K. / Phillips, M.A. |
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Methods | X-ray diffraction |
Resolution | 1.23 - 2.07 Å |
Structure data | ![]() PDB-4oqv: ![]() PDB-4ori: ![]() PDB-4orm: |
Chemicals | ![]() ChemComp-FMN: ![]() ChemComp-ORO: ![]() ChemComp-2V6: ![]() ChemComp-ACY: ![]() ChemComp-GOL: ![]() ChemComp-NA: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Alpha/Beta Barrel / REDOX / DEHYDROGENASE / FMN / mitochondrial membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / Oxidoreductase |