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Structure paper

TitleTetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 158, Page 1136-1147, Year 2014
Publish dateJan 6, 2014 (structure data deposition date)
AuthorsTschowri, N. / Schumacher, M.A. / Schlimpert, S. / Chinnam, N.B. / Findlay, K.C. / Brennan, R.G. / Buttner, M.J.
External linksCell(Cambridge,Mass. ) / PubMed:25171413
MethodsX-ray diffraction
Resolution1.7501 - 2.8 Å
Structure data

PDB-4oay:
BldD CTD-c-di-GMP complex
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-4oaz:
BldD CTD-c-di-GMP complex
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-4ob4:
Structure of the S. venezulae BldD DNA-binding domain
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5khd:
Structure of 1.75 A BldD C-domain-c-di-GMP complex
Method: X-RAY DIFFRACTION / Resolution: 1.7501 Å

Chemicals

ChemComp-C2E:
9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)

ChemComp-HOH:
WATER

Source
  • streptomyces venezuelae (bacteria)
  • streptomyces coelicolor (bacteria)
  • streptomyces coelicolor a3(2) (bacteria)
KeywordsDNA BINDING PROTEIN / BldD / small molecule dimerizer / c-di-GMP / dimerizer / BldD DNA binding domain / helix turn helix / streptomyces

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