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-Structure paper
Title | Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 360-366, Year 2014 |
Publish date | Jun 30, 2013 (structure data deposition date) |
![]() | Murphy-Benenato, K. / Wang, H. / McGuire, H.M. / Davis, H.E. / Gao, N. / Prince, D.B. / Jahic, H. / Stokes, S.S. / Boriack-Sjodin, P.A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.65 - 1.9 Å |
Structure data | ![]() PDB-4lh6: ![]() PDB-4lh7: |
Chemicals | ![]() ChemComp-1X7: ![]() ChemComp-NMN: ![]() ChemComp-ACT: ![]() ChemComp-NA: ![]() ChemComp-HOH: ![]() ChemComp-1X8: |
Source |
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![]() | LIGASE/LIGASE INHIBITOR / Protein-inhibitor complex / LIGASE-LIGASE INHIBITOR complex |